NYPD Detective Danny Reagan takes a job with the Boston PD and is paired with Detective Lena Silver, part of a law enforcement family comprised of District Attorney Mae Silver, Police Superintendent Sarah Silver, rookie cop Jonah Silver and Rev. Edwin Peters. Reagan hopes to reconnect with his son, Sean, in Boston.

When a misfit group of unwitting high school students stumbles upon a cursed Aztec Death Whistle, they discover that blowing it unleashes a terrifying sound that summons their future deaths to hunt them down.