Couple Friendly follows the journey of a Telugu boy and girl who both reside in Chennai. Their paths cross under unique circumstances, and the story deals with the challenges they face in their careers and relationship. Set in a city where they don't speak their mother tongue, the film explores the emotional highs and lows of navigating life and love in an unfamiliar environment.

Haunted by an astrological prophecy, Kamsaraja relentlessly torments his sister's family, believing her child will be his doom. Even in imprisonment, Krishna protects the family from Kamsaraja's evil plans.