James Pittman is a burnt-out photography professor who goes on sabbatical and straight into a mid-life crisis. A young artist named Lucy comes into his life and he tries desperately to recapture the lost spirit of his youth.

When his home of New Eden is destroyed by a revitalized Brotherhood and its new Vamp leader, Martin finds himself alone in the badlands of America with only the distant memory of his mentor and legendary vampire hunter, Mister, to guide him.