After Nao Kanzaki receives a strange letter and a suitcase containing 100 million yen, she learns that she has been selected to participate in the LIAR GAME. Nao turns to a former con artist to survive the twisted game.

In the future, humanity wages war with giant humanoid weapons called Titanostrides. Isami Ao of the Japan Ground Self-Defense Force and Lewis Smith of the United States Marine Corps meet on the battlefield in Oahu, Hawaii. An enemy aircraft attacks, scattering their forces. To survive the battle and save their friends, unlikely comrades must find the courage to defeat this new threat.

After human experimentation turns Kisaragi into a cyborg, he finds himself pressured by multiple organizations.