Painted skin masters wield a mystical brush that alters appearance and fate. Fang Ji, thought dead decades ago, lives on, bound by duty and tradition. His cheerful apprentice, Mu Yiqian, once a wealthy youth, gives up luxury to follow Fang Ji on a hidden journey, keeping the ancient art alive through secret mentorship and sacrifice.

In a demon-plagued world, gifted humans fight back. Some "Skin Painters" can transform decay into magic, reshaping bodies with their brushes. The final generation faces a flesh-eating creature.