After an elderly woman discovers a mysterious amulet that restores her youth by draining the life from those around her, her caregiver must stop her as an entire town withers in a grotesque battle over renewal and the terror of aging.

In a small Wisconsin lake town, a poverty-stricken felon contracts a novel prions disease after ingesting tainted venison. As his descent into madness intensifies, he targets a Chicago musician and a mysterious singer, whose dream of recording an album together is threatened by the felon's violent unraveling.