30 years after the events of The Brothers McMullen, romantic entanglements plague a now fiftysomething Barry McMullen and his twentysomething kids, as well as his brother Patrick and widowed sister-in-law Molly, who are also facing similar unexpected hurdles.

After a college student and her two best friends frantically rush home to care for her mysteriously demented PawPaw, he disappears. A street reformed Auntie, homeless informants, and a host of others must help them find him before it's too late.