O'Grady chronicles the lives of high school students Abby and Kevin, along with those of other residents of O'Grady, a fictional town which is periodically plagued by "The Weirdness." The Weirdness affects its residents in strange ways, such as projecting their private thoughts in bubbles over their heads, or producing clones of themselves every time they get angry.

Brendon Small, an ambitious eight-year-old filmmaker, shoots movies in his basement with his two best friends, while coming to terms with adolescence, life, and relationships.

Two ducks fly around in a rocket-powered van, delivering bread to other ducks in Pondgea.