East Shinjuku Night High School has students with various challenges. Delinquent Taketo is trapped in a negative spiral. Filipina-Japanese Angela struggles with schoolwork, while Kasumi spends all her class hours in the infirmary. Shozo had to leave school to work in his youth. With guidance from their new science teacher, Fujitake, they work on an experiment for an academic conference.

Diverse cast of troubled characters including hosts, hostesses, homeless, Tokoyoko kids, and refugees. Kankuro's humorous take on emergency medical dramas highlighting life's value despite worries.

Professor Shiro Sakaki, a butterfly researcher, confesses to turning six young boys, including his own son Itaru, into "human specimens."

Hana, a high school student who lost her parents in an accident, does not fit in at school and cannot find any reason to live. Suddenly one day, a man claiming to be from a special government organization visits her and asks her to tell him about a dream she had. Hana is confused and has no idea what is happening, but that night she has a strange dream.